Reference

Lemiere C, Cartier A, Malo JL et al, Persistent specific bronchial reactivity to occupational agents in workers with normal nonspecific bronchial reactivity, Am J Respir Crit Care Med, 2000;162:976-980,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

16 workers with occupational asthma caused by the high-molecular-weight-agents flour, psyllium and guar gum were re-exposed to assess their current specific bronchial reactivity (SBR) to the sensitisers (removed from exposure for a mean period of 5.7 years). Concludes that SBR to such agents persists in most cases (11/16) despite a normalisation of NSBR, and that this persistence is associated with a persistence of specific immunisation to the agent. IgE significantly decreased and at lower level at time of second challenge in those not experiencing an asthmatic reaction.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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A large number of concordant studies from different centres using different methodologies demonstrated that increased non-specific reactivity is often found in workers with occupational asthma. There are however many reports of normal methacholine or histamine reactivity within 24 hours of exposure in workers with confirmed occupational asthma.

Non Bohrf Information

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