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Chemical structure-function analysis identifies further respiratory sensitisers

Chemical structure-function analysis identifies further respiratory sensitisers

This paper updates the original with further identified sensitisers. The predictive model worked well but did not not predicted 3 of the new occupational allergens, sevofluorane, eugenol and a benzoic acid derivative. Is the predictive model sufficiently good to suggest that these might be acting via alternative mechanisms?

References

Abstract Available for Further validation of computer-based prediction of chemical asthma hazard Seed M, Agius R, Further validation of computer-based prediction of chemical asthma hazard, Occup Med, 2010;60:115-120,
Raymond Agius, Centre for Occupational and Environmental Health, Manchester University, an author of 'Further validation of computer-based prediction of chemical asthma hazard' Martin Seed, Manchester University, an author of 'Further validation of computer-based prediction of chemical asthma hazard'

Full Text Available for Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds Jarvis J, Seed MJ, Elton R, Sawyer L, Agius R, Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds, Occup Environ Med, 2005;62:243-250,
Raymond Agius, Centre for Occupational and Environmental Health, Manchester University, an author of 'Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds' Martin Seed, Manchester University, an author of 'Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds'

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