Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 5000 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Shooting is bad for your health Shooting is bad for your health 30 04 2017
Occupational asthma: Is the occupational asthma in laboratory animal workers with negative specific IgE due to irritation? Is the occupational asthma in laboratory animal workers with negative specific IgE due to irritation? 30 04 2017
Occupational asthma: Anti-IgE effective in mouse model of persulphate asthma Anti-IgE effective in mouse model of persulphate asthma 29 04 2017
Occupational asthma: Ask patients with hypersensitivity pneumonitis whether they play a wind instrument Ask patients with hypersensitivity pneumonitis whether they play a wind instrument 28 03 2017
Occupational asthma: Why does respiratory surveillance fail to detect new onset occupational asthma? Why does respiratory surveillance fail to detect new onset occupational asthma? 17 03 2017

Latest Publications

Abstract Available for Military small arms fire in association with acute decrements in lung function Borander AK, Voie ØA, Longva K, Danielsen TE, Grahnstedt S, Sandvik L, Kongerud J, Sikkeland LIB, Military small arms fire in association with acute decrements in lung function, Occup Environ Med, 2017;:,org/10.1136/oemed-2016-104207
Johny Kongerud, Rikshospitalet, Oslo University, Norway, an author of 'Military small arms fire in association with acute decrements in lung function'

Abstract Available for Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals. Lemaire M, Oppliger A, Hotz P, Renauld JC, Braun J, Maggi M, Barresi F, Schmid-Grendelmeier P, Huaux F, Dressel H., Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals., Occup Environ Med, 2017;:,10.1136/oemed-2016-104137
Holger Dressel, Institute of Occupational and Environmental Medicine, Munich, an author of 'Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals.'

Abstract Available for Opportunities and obstacles in translating evidence to policy in occupational asthma Tarlo SM, Arif AA, Delclos GL, Henneberger P, Patel J, Opportunities and obstacles in translating evidence to policy in occupational asthma, Annals of Epidemiology, 2017;:,DOI: http://dx.doi.org/10.1016/j.annepidem.2017.03.002
Paul Henneberger, NIOSH, Morgantown, USA, an author of 'Opportunities and obstacles in translating evidence to policy in occupational asthma' Susan Tarlo, Toronto, an author of 'Opportunities and obstacles in translating evidence to policy in occupational asthma' Ahmed Arif, University of North Carolina, an author of 'Opportunities and obstacles in translating evidence to policy in occupational asthma'

Go to "References" section.

Latest Forum Questions

Comments for the paper: "Military small arms fire in association with acute decrements in lung function", 2017, Occup Environ Med
Could this be due to tetrazine sensitisation from the detonator?
Published Paper Comments, , 4/30/2017, 4/30/2017,

Comments for the paper: "Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals.", 2017, Occup
Studies of laboratory animal allergy have consistently shown a large number of workers with work-related asthma or rhinitis but negative IgE to rat and mouse allergens. The current study starts with the hypothesis that those with negative IgE have irritant responses to the animal allergens and can be safely redeployed to areas with some but lesser exposure. If true this is important, but I believe not yet substantiated. The cross-sectional study identified 29 with work-related symptoms and negative IgE, and found their cytokine profiles indistinguishable from workers with negative IgE and no symptoms. They did however fall into 2 subsets with raised IL17A with and without raised IL8. The study was compromised by finding only 8 workers with positive IgE and work-related symptoms. The authors concluded that "In this unselected population of LA workers, the profile ‘irritation’ did not prove to be a valuable health surveillance tool. Low power precluded assessment of the profile ‘sensitiser’. The increased IL-17A concentration may originate from irritative constituents of organic dust.
Published Paper Comments, , 4/30/2017, 4/30/2017,

Comments for the paper: "Effect of anti-IgE in occupational asthma caused by exposure to low molecular weight agents.", 2017, Allergy
This is an interesting study showing that anti-IgE in the mouse reduces the effects of nasal challenge with persulphates in dermally sensitised mice. There is some controversy on the role of IgE antibodies in human persulphate asthma, but this study paves the way for a trial in man (or women).
Published Paper Comments, , 4/29/2017, 4/29/2017,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets about every 6 weeks on a Wednesday evening, as shown below.

Oasys Team

As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Geraldine Burge, Birmingham Heartlands Hospital Burge, Geraldine (Birmingham Heartlands Hospital)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Johny Kongerud, Rikshospitalet, Oslo University, Norway Kongerud, Johny (Rikshospitalet, Oslo University, Norway)
Paul Henneberger, NIOSH, Morgantown, USA Henneberger, Paul (NIOSH, Morgantown, USA)
Kjell Toren, Sahlgrenska University Hospital. Goteborg Toren, Kjell (Sahlgrenska University Hospital. Goteborg)
Hille Suojalehto, Finnish Institute of Occupational Health Suojalehto, Hille (Finnish Institute of Occupational Health)
Irmeli Lindstrom, Finnish Institute of Occupational Health Lindstrom, Irmeli (Finnish Institute of Occupational Health)
Dan Norback, Norback, Dan ()
Cecile Svanes, University of Bergen, Norway Svanes, Cecile (University of Bergen, Norway)
Vivi Schlunssen, Aarhus Schlunssen, Vivi (Aarhus)
John Reynolds, Birmingham Heartlands Hospital Reynolds, John (Birmingham Heartlands Hospital)
Jan-Paul Zock, Municipal Institute of Medical Research, Barcelona, Spain Zock, Jan-Paul (Municipal Institute of Medical Research, Barcelona, Spain)

Known Authors

Holger Dressel, Institute of Occupational and Environmental Medicine, Munich Dressel, Holger (Institute of Occupational and Environmental Medicine, Munich)
Ahmed Arif, University of North Carolina Arif, Ahmed (University of North Carolina)
Susan Tarlo, Toronto Tarlo, Susan (Toronto)
Xavier Munoz, Barcelona Munoz, Xavier (Barcelona)
Maria Jesus Cruz, Barcelona Cruz, Maria Jesus (Barcelona)
Susana Gomez-Olles, Barcelona Gomez-Olles, Susana (Barcelona)
Susana Gomez-Olles, Barcelona Gomez-Olles, Susana (Barcelona)
Dick Heederik, Institute of Risk Assessment Sciences, Utrecht Heederik, Dick (Institute of Risk Assessment Sciences, Utrecht)
Eva Andersson, Andersson, Eva ()
Orianne Dumas, Villejuif, France Dumas, Orianne (Villejuif, France)

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