Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 5000 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Diagnosis of occupational eosinophilic bronchitis Diagnosis of occupational eosinophilic bronchitis 24 09 2020
Occupational asthma: Significant late asthmatic reactions defined by values outside 95% CI for control days identifies late reactions with smaller changes in FEV1 Significant late asthmatic reactions defined by values outside 95% CI for control days identifies late reactions with smaller changes in FEV1 16 08 2020
Occupational asthma: Cassava milling a potent cause of occupational asthma Cassava milling a potent cause of occupational asthma 15 08 2020
Occupational asthma: Validation of the Canadian score for predicting positive specific challenges to high molecular weight agents Validation of the Canadian score for predicting positive specific challenges to high molecular weight agents 15 08 2020
Occupational asthma: Referrals from occupational health services  improves the prognosis of occupational asthma Referrals from occupational health services improves the prognosis of occupational asthma 10 07 2020

Latest Publications

Full Text Available for Upper and Lower Respiratory Signs and Symptoms in Workers Occupationally Exposed to Flour Dust Crivellaro MA, Ottaviano G, Maculan P, Pendolino AL, Vianello L, Mason P, Gioffrè F, Bizzotto R, Scarpa B, Simoni E, Astolfi L, Maestrelli P, Scapellato ML, Carrieri M, Trevisan A, Upper and Lower Respiratory Signs and Symptoms in Workers Occupationally Exposed to Flour Dust, Int. J. Environ. Res. Public Health, 2020;17:7075,
Piero Maestrelli, Padova University, Italy, an author of 'Upper and Lower Respiratory Signs and Symptoms in Workers Occupationally Exposed to Flour Dust'

No Abstract Available for Why are Cases of Occupational Asthma on the Rise?? Williams N, Why are Cases of Occupational Asthma on the Rise??, Occup Med, 2020;70:399,https://doi.org/10.1093/occmed/kqaa064
Nerys Williams, Department of Work and Pensions, an author of 'Why are Cases of Occupational Asthma on the Rise??'

Abstract Available for The Role of Immunotherapy and Biologic Treatments in Occupational Allergic Disease Smith AM, Sastre J, The Role of Immunotherapy and Biologic Treatments in Occupational Allergic Disease, Journal of Allergy and Clinical Immunology: In Practice, 2020;:,https://doi.org/10.1016/j.jaip.2020.07.042
Joaquin Sastre, Fundacion Jimenez Diaz, Madrid, an author of 'The Role of Immunotherapy and Biologic Treatments in Occupational Allergic Disease'

Go to "References" section.

Latest Forum Questions

Comments for the paper: "Acute hypersensitivity pneumonitis in woodworkers caused by inhalation of birch dust contaminated with Pantoea agglomerans and Microbacterium barkeri", 2019, Annals of Agricu
This is a new cause for hypersensitivity pneumonitis in furniture manufacturers starting after switching from Scots Pine to Birch wood. Unusually the cause was the microbes present in high concentration in healthy sap wood rather than from the wood itself, demonstrated with specific inhalation challenges.
Published Paper Comments, , 9/5/2020, 10/19/2020,

Comments for the paper: "Identification of late asthmatic reactions following specific inhalation challenge", 2020, Occup Environ Med
Specific inhalation tests are more difficult to perform in workers who have isolated late asthmatic reactions, as more caution is needed increasing exposures. Defining a late asthmatic reaction outside the 95% CI for control days allows identification of late reactions with lower percentage change in FEV1 in those with initial values >2.5 litres, however 3 control days are needed. This paper reports the results when 2 of the 3 control days are done unsupervised at home, with the third day following control exposure in the laboratory. The pooled SD method for defining late asthmatic reactions has scientific validity, accounts for interpatient spirometric variability and diurnal variation.
Published Paper Comments, , 10/2/2020, 10/4/2020,

Comments for the paper: "Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms", 2020, J Allergy Clin Immunol Pract.
Eosinophilic bronchitis was defined as an increase in sputum eosinophilia of >=3% 24 hours post SIC, with no NSBR and a fall in FEV1 <15%. The eosinophilic bronchitis group had more cough, higher FEV1 and a shorter period of work-related symptoms than those with a positive SIC, raising the possibility that this is an early stage of eosinophilic occupational asthma rather than a separate disease. Measuring sputum eosinophilia is unpleasant for the patient and time consuming for the staff, unfortunately this study showed that increases in FeNO (which is much easier to measure) had a poor sensitivity for detecting the >3% increase in sputum eosinophilia (an increase of 8ppb had a specificity of 90% and a sensitivity of 43%). This study critically depends on the 15% cut off for a positive SIC, the FEV1 changes post SIC are not given in the paper. I would be much happier if the disease was defined by changes found following usual exposures at work, rather than the artificial (but controlled) exposures in the laboratory.
Published Paper Comments, , 9/24/2020, 9/24/2020,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets about every 6 weeks on a Wednesday evening, as shown below.



As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Geraldine Burge, Birmingham Heartlands Hospital Burge, Geraldine (Birmingham Heartlands Hospital)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
Mike Hendy, Oasys Hendy, Mike (Oasys)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Piero Maestrelli, Padova University, Italy Maestrelli, Piero (Padova University, Italy)
Nerys Williams, Department of Work and Pensions Williams, Nerys (Department of Work and Pensions)
Simon Trotter, Birmingham Heartlands Hospital Trotter, Simon (Birmingham Heartlands Hospital)
Darsana Viswam, University Hospitals Birmingham Viswam, Darsana (University Hospitals Birmingham)
Hille Suojalehto, Finnish Institute of Occupational Health Suojalehto, Hille (Finnish Institute of Occupational Health)
Paul Henneberger, NIOSH, Morgantown, USA Henneberger, Paul (NIOSH, Morgantown, USA)
Olivier Vandenplas, Universite Mont-Goginne, Yvoir Vandenplas, Olivier (Universite Mont-Goginne, Yvoir)
Paul Cullinan, Royal Brompton Hospital, London, UK Cullinan, Paul (Royal Brompton Hospital, London, UK)
Julie Cannon, Royal Brompton Hospital London Cannon, Julie (Royal Brompton Hospital London)
Joanna Szram, Royal Brompton Hospital Szram, Joanna (Royal Brompton Hospital)

Known Authors

Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Sastre, Joaquin (Fundacion Jimenez Diaz, Madrid)
Xavier Munoz, Barcelona Munoz, Xavier (Barcelona)
Ahmed Arif, University of North Carolina Arif, Ahmed (University of North Carolina)
Eva Andersson, Andersson, Eva ()
Stephan Keirsbilck, IDEWE occupational Health Belgium Keirsbilck, Stephan (IDEWE occupational Health Belgium)
Laurens de Sadeleer, University Hospitals Leuven, Leuven B-3000, Belgium de Sadeleer, Laurens (University Hospitals Leuven, Leuven B-3000, Belgium)
Raymond Agius, Centre for Occupational and Environmental Health, Manchester University Agius, Raymond (Centre for Occupational and Environmental Health, Manchester University)
Martin Seed, Manchester University Seed, Martin (Manchester University)
Rolf Merget, Bochum Merget, Rolf (Bochum)
Santiago Quirce, Madrid Quirce, Santiago (Madrid)

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