Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 5000 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Occupational asthma from low level exposure to pure cellulose, implications for the paper and cardboard industries? Occupational asthma from low level exposure to pure cellulose, implications for the paper and cardboard industries? 14 02 2019
Occupational asthma: Smartphone app with bar code reader identifies  asthmagens in cleaning agents Smartphone app with bar code reader identifies asthmagens in cleaning agent 06 02 2019
Occupational asthma: Cleaning agents now the commest cause of occupational asthma in Slovakia Cleaning agents now the commest cause of occupational asthma in Slovakia 17 01 2019
Occupational asthma: Reduced lung function in Ethiopian coffee workers Reduced lung function in Ethiopian coffee workers 03 01 2019
Occupational asthma: Respiratory and cutaneous reactions to cannabis are common in police workers Respiratory and cutaneous reactions to cannabis are common in police workers 01 01 2019

Latest Publications

Abstract Available for Emerging trends in the UK incidence of occupational asthma: should we be worried? Seed MJ, Carder M, Gittins M, Sen D, Money A, Fishwick D, Barber CM, van Tongeren M., Emerging trends in the UK incidence of occupational asthma: should we be worried?, Occup Environ Med, 2019;:,10.1136/oemed-2018-105414
David Fishwick, Royal Hallamshire Hospital, Sheffield, UK, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?' Chris Barber, Health and Safety Laboratories, Buxton, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?' Martin Seed, Manchester University, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?' Dil Sen, Health and Safety Executive, UK, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?' Annemarie Money, Manchester University, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?' Melanie Carder, COEH Manchester, an author of 'Emerging trends in the UK incidence of occupational asthma: should we be worried?'

Abstract Available for Occupational asthma caused by peracetic acid-hydrogen peroxide mixture Walters GI, Burge PS, Moore VC, Thomas MO, Robertson AS, Occupational asthma caused by peracetic acid-hydrogen peroxide mixture, Occup Med, 2019;:,DOI: 10.1093/occmed/kqz032
Sherwood Burge, Oasys, an author of 'Occupational asthma caused by peracetic acid-hydrogen peroxide mixture' Vicky Moore, Oasys, an author of 'Occupational asthma caused by peracetic acid-hydrogen peroxide mixture' Alastair Robertson, Selly Oak Hospital, an author of 'Occupational asthma caused by peracetic acid-hydrogen peroxide mixture' Gareth Walters, Heartlands, an author of 'Occupational asthma caused by peracetic acid-hydrogen peroxide mixture'

Full Text Available for Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR Cannon J, Fitzgerald B, Seed M, Agius R, Jiwany A, Cullinan P, Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR , Occup Med, 2015;65:256-258,https://doi.org/10.1093/occmed/kqu193
Paul Cullinan, Royal Brompton Hospital, London, UK, an author of 'Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR' Raymond Agius, Centre for Occupational and Environmental Health, Manchester University, an author of 'Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR' Martin Seed, Manchester University, an author of 'Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR' Julie Cannon, Royal Brompton Hospital London, an author of 'Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR'

Go to "References" section.

Latest Forum Questions

Optimal days working and days off work
I have a office worker that complains from asthma exacerbation during work by the air conditioning. I checked the literature that says peak flow measures must be done 2 week at work and 2 weeks off work but Oasys tutorial does not define the optimal ratio of days working and days off at peak flow measures. Wich proportion would give the best results?
Occupational Asthma, Health Professional, 3/11/2019, 3/11/2019,

Comments for the paper: "Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis.", 2019, Occup Environ Med
This meta-analysis seems to omit rodent allergens, which do not get a mention despite many studies, perhaps there are few with specific challenges, but this is not mentioned in the text. There is no discussion of genetically modified allergens, particularly enzymes, or the effects of isocyanate pre-polymers, which reduce the sensitivity of tests with native allergens. Despite these problems the sensitivity of all tests is <100% (commonly around 80% for high molecular weight allergens). The problems with specificity are not mentioned, if the specificity is measured against a negative specific challenge, as stated in the methods, there will be very little data for analysis.
Published Paper Comments, , 3/7/2019, 3/7/2019,

Comments for the paper: "Performance of specific immunoglobulin E tests for diagnosing occupational asthma: a systematic review and meta-analysis.", 2019, Occup Environ Med
This meta-analysis seems to omit rodent allergens, which do not get a mention despite many studies, perhaps there are few with specific challenges, but this is not mentioned in the text. There is no discussion of genetically modified allergens, particularly enzymes, or the effects of isocyanate pre-polymers, which reduce the sensitivity of tests with native allergens. Despite these problems the sensitivity of all tests is <100% (commonly around 80% for high molecular weight allergens). The problems with specificity are not mentioned, if the specificity is measured against a negative specific challenge, as stated in the methods, there will be very little data for analysis.
Published Paper Comments, , 3/7/2019, 3/7/2019,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets about every 6 weeks on a Wednesday evening, as shown below.



As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Geraldine Burge, Birmingham Heartlands Hospital Burge, Geraldine (Birmingham Heartlands Hospital)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
Mike Hendy, Oasys Hendy, Mike (Oasys)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Chris Barber, Health and Safety Laboratories, Buxton Barber, Chris (Health and Safety Laboratories, Buxton)
Melanie Carder, COEH Manchester Carder, Melanie (COEH Manchester)
Annemarie Money, Manchester University Money, Annemarie (Manchester University)
David Fishwick, Royal Hallamshire Hospital, Sheffield, UK Fishwick, David (Royal Hallamshire Hospital, Sheffield, UK)
Paul Cullinan, Royal Brompton Hospital, London, UK Cullinan, Paul (Royal Brompton Hospital, London, UK)
Julie Cannon, Royal Brompton Hospital London Cannon, Julie (Royal Brompton Hospital London)
Xaver Baur, Institute of occupational medicine, Hamburg Baur, Xaver (Institute of occupational medicine, Hamburg)
Meinir Jones, Royal Brompton Hospital, London Jones, Meinir (Royal Brompton Hospital, London)
Keith Palmer, Environmental Epidemiology Unit, Southampton University, UK Palmer, Keith (Environmental Epidemiology Unit, Southampton University, UK)
Josep Antó, Barcelona, Catalonia, Spain Antó, Josep (Barcelona, Catalonia, Spain)

Known Authors

Martin Seed, Manchester University Seed, Martin (Manchester University)
Dil Sen, Health and Safety Executive, UK Sen, Dil (Health and Safety Executive, UK)
Raymond Agius, Centre for Occupational and Environmental Health, Manchester University Agius, Raymond (Centre for Occupational and Environmental Health, Manchester University)
Martin Hetzel, Bristol Royal Infirmary Hetzel, Martin (Bristol Royal Infirmary)
Tim Clark, Royal Brompton Hospital Clark, Tim (Royal Brompton Hospital)
Mohammed Jeebhay, Cape Town Jeebhay, Mohammed (Cape Town)
David Coggon, Southampton University Coggon, David (Southampton University)
Orianne Dumas, Villejuif, France Dumas, Orianne (Villejuif, France)
Paul Blanc, University of California San Francisco Blanc, Paul (University of California San Francisco)
Torben Sigsgaard, University of Aarhus Sigsgaard, Torben (University of Aarhus)

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