Reference

Jeal H, Draper A, Jones M, Harris J, Welsh K, Newman Taylor AJ, HLA associations with occupational sensitisation to rat lipocalin allergens: a model for other animal allergies?, J Allergy Clin Immunol, 2003;111:795-799,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Figures suggest that approximately 40% of occupational asthma in this laboratory animal worker population can be attributed to an HLA-DRß1*07 phenotype; in comparison, attributable proportions for atopy and daily work in an animal housing facility are 58% and 74% respectively. Sensitised individuals were twice as likely to be HLA-DRß*07-positive and half as likely to be HLA-DRß*03 positive. HLA-DRß1*07 was also, and more strongly independently associated with work-related chest symptoms. Among employees similarly exposed to rats in their work, those who developed symptomatic sensitisation to rat urinary protein are nearly 4 times as likely to be HLA-DRß1*07-positive as those who remained unsensitised and asymptomatic.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

***

2++

Atopy increases the risk of developing occupational asthma caused by exposure to many high molecular weight agents that induce the production of specific IgE antibodies.

Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

Non Bohrf Information

This page is showing the information from the BOHRF occupational asthma guidelines for this reference. To see additional information, including opinions left by users of this website please view the full reference. This page allows users to comment on the reference and suggest it as evidence for questions. These may be the existing questions from the Bohrf occupational asthma guidelines or questions that have been put forward by users of this website.