Is there a genetic predisposition for developing occupational asthma?

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Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

Evidence

Balboni A, Baricordi OR, Fabbri LM, Gandini E, Ciaccia A, Mapp CE , Association between toluene di-isocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57 , Eur Respir J , 1996 ; 9 : 207-210

Bignon JS, Aron Y, Ju LY et al , HLA class II alleles in isocyanate-induced asthma , Am J Respir Crit Care Med , 1994 ; 149 : 71-75

Horne C, Quintana PJ, Keown PA et al , Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar , Eur Respir J , 2000 ; 15 : 911-914

Jeal H, Draper A, Jones M, Harris J, Welsh K, Newman Taylor AJ , HLA associations with occupational sensitisation to rat lipocalin allergens: a model for other animal allergies? , J Allergy Clin Immunol , 2003 ; 111 : 795-799

Mapp CE, Beghe B, Balboni A et al , Association between hla genes and susceptibility to toluene di-isocyanate-induced asthma , Clin Exp Allergy , 2000 ; 30 : 651-656

Mapp CE, Fryer AA, DeMarzo N et al , Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates , J Allergy Clin Immunol , 2002 ; 109 : 867-872