Occupational Asthma Reference

Davison AG, Haslam PL, Corrin B, Coutts II, Dewar A, Riding WD, Studdy PR, Newman Taylor AJ, Interstitial lung disease and asthma in hard metal workers: bronchoalveolar lavage, ultrastructural and analytical findings and results of bronchial provocation tests, Thorax, 1983;38:119-128,

Keywords: oa, hard metal, as , alveolitis, key, ch, bal, hi, cobalt

Known Authors

Tony Newman Taylor, Royal Brompton Hospital, London Tony Newman Taylor

Tony Davison, Southend Hospital, UK Tony Davison

Bryan Corrin, Royal Brompton Hospital Bryan Corrin

Ian Coutts, Brompton Hospital and Cornwall Ian Coutts

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Five patients with respiratory disorders associated with hard metal exposure are described. In four patients electron microprobe analysis of bronchoalveolar lavage cells or lung tissue was used to show tungsten and other hard-metal components. Three patients had interstitial pneumonia and fibrosis with unusual multinucleate giant cells. Electron microscopy showed that the giant cells comprised both type II alveolar epithelial cells and alveolar macrophages. The multinucleate macrophages formed a distinctive feature of the bronchoalveolar lavage material but the multinucleate alveolar epithelial lining cells were evident only in lung tissue. The other two patients both suffered from work-related asthma, one of whom also had pulmonary opacities. Bronchial provocation tests in these patients supported the diagnosis of hard-metal-induced asthma and implicated cobalt as the agent responsible.

Full Text

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo