Occupational Asthma Reference

Baatjies R, Jeebhay MF, Sensitisation to cereal flour allergens is a major determinant of elevated exhaled nitric oxide in bakers, Occup Environ Med, 2013;70:310-316,

Keywords: South Africa, NO, Baker, wheat, Rye, epidemiology, cross-section, rhinitis, asthma, OA

Known Authors

Mohammed Jeebhay, Cape Town Mohammed Jeebhay

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Objective
Various studies of the usefulness of fractional exhaled nitric oxide (FeNO) in occupational settings remain inconclusive. The objective was to investigate the determinants of increased FeNO in bakery workers.

Methods
A cross-sectional study of 424 supermarket bakery workers used a questionnaire and serum specific IgE to wheat, rye and a-amylase. FeNO during the work shift were assessed using a hand-held portable sampling device (NIOX MINO).

Results
The median FeNO was 15 ppb, in atopics 21 ppb and current smokers 12 ppb. Increased FeNO was strongly associated with IgE to wheat independent of smoking and atopy status. In the multivariate model, IgE to wheat, current smoking, atopy and age were significantly associated with FeNO. Stratified analysis in a subgroup of atopic non-smokers demonstrated the strongest relationship between FeNO and various clinical endpoint such as wheat (OR=9.43) or rye (OR=11.76) sensitisation, work-related allergic rhinitis (OR=8.13) or asthma (OR=5.44), and probable baker's asthma (OR=6.72).

Conclusions
Sensitisation to cereal flour allergens rather than asthma symptoms is a major determinant of elevated FeNO among bakers. This relationship is modified by atopy and current smoking status.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo