Occupational Asthma Reference

Ghosh RE, Cullinan P, Fishwick D, Hoyle J, Warburton CJ, Strachan DP, Butland BK, Jarvis D, Asthma and occupation in the 1958 birth cohort, Thorax, 2013;68:365-371,

Keywords: UK, general popolation, cleaners, waiters, bakers, population attributable risk, JEM, farmer, hairdresser, printers, enzymes, metal fumes, textiules,

Known Authors

Paul Cullinan, Royal Brompton Hospital, London, UK Paul Cullinan

David Fishwick, Royal Hallamshire Hospital, Sheffield, UK David Fishwick

Chris Warburton, Liverpool Chris Warburton

Jennifer Hoyle, North Manchester General Hospital Jennifer Hoyle

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Abstract

Objective
To examine the association of adult onset asthma with lifetime exposure to occupations and occupational exposures.

Methods
We generated lifetime occupational histories for 9488 members of the British 1958 birth cohort up to age 42 years. Blind to asthma status, jobs were coded to the International Standard Classification of Occupations 1988 and an Asthma Specific Job Exposure Matrix (ASJEM) with an expert re-evaluation step. Associations of jobs and ASJEM exposures with adult onset asthma were assessed in logistic regression models adjusting for sex, smoking, social class at birth and childhood hay fever.

Results
Of the 7406 cohort members with no asthma or wheezy bronchitis in childhood, 639 (9%) reported asthma by age 42 years. Adult onset asthma was associated with 18 occupations, many previously identified as risks for asthma (eg, farmers: OR 4.26, 95% CI 2.06 to 8.80; hairdressers: OR 1.88, 95% CI 1.24 to 2.85; printing workers: OR 3.04, 95% CI 1.49 to 6.18). Four were cleaning occupations and a further three occupations were likely to use cleaning agents. Adult onset asthma was associated with five of the 18 high-risk specific ASJEM exposures (flour exposure: OR 2.12, 95% CI 1.17 to 3.85; enzyme exposure: OR 2.32, 95% CI 1.22 to 4.42; cleaning/disinfecting products: OR 1.67, 95% CI 1.26 to 2.22; metal and metal fumes: OR 1.45, 95% CI 1.02 to 2.07; textile production: OR 1.71, 95% CI 1.12 to 2.61). Approximately 16% (95% CI 3.8% to 27.1%) of adult onset asthma was associated with known asthmagenic occupational exposures.

Conclusions
This study suggests that about 16% of adult onset asthma in British adults born in the late 1950s could be due to occupational exposures, mainly recognised high-risk exposures. WA

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