Occupational Asthma Reference

Jacobsen GH, Schlünssen V, Schaumburg I, Sigsgaard T, Cross-shift and longitudinal changes in FEV1 among wood dust exposed workers, Occup Environ Med, 2013;70:22-28,
(Plain text: Jacobsen GH, Schlunssen V, Schaumburg I, Sigsgaard T, Cross-shift and longitudinal changes in FEV1 among wood dust exposed workers, Occup Environ Med)

Keywords: Denmark, wood, FEV1, longitudinal study, post-shift

Known Authors

Torben Sigsgaard, University of Aarhus Torben Sigsgaard

Vivi Schlunssen, Aarhus Vivi Schlunssen

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Abstract

Objectives
Acute lung function (LF) changes might predict an accelerated decline in LF. In this study, we investigated the association between cross-shift and longitudinal changes in forced expiratory volume in 1 s (FEV1) among woodworkers in a 6-year follow-up study.

Methods
817 woodworkers and 136 controls participated with cross-shift changes of FEV1 at baseline and FEV1 and forced vital capacity at follow-up. Height and weight were measured and questionnaire information on respiratory symptoms, employment and smoking habits was collected. Wood dust exposure was assessed from 3572 personal dust measurements at baseline and follow-up. Cumulative wood dust exposure was assessed by a study-specific job exposure matrix and exposure time.

Results
The median (range) of inhalable dust at baseline and cumulative wood dust exposure was 1.0 (0.2–9.8) mg/m3 and 3.8 (0–7.1) mg year/m3, respectively. Mean (SD) for %?FEV1/workday and ?FEV1/year was 0.2 (6.0)%, and -29.1 (41.8) ml. Linear regression models adjusting for smoking, age, height and weight change showed no association between cross-shift and annual change in FEV1 among woodworkers or controls. Including different exposure estimates, atopy or cross-shift change dichotomised or as quartiles did not change the results.

Conclusions
This study among workers exposed to low levels of wood dust does not support an association between acute LF changes and accelerated LF decline.

Plain text: Objectives Acute lung function (LF) changes might predict an accelerated decline in LF. In this study, we investigated the association between cross-shift and longitudinal changes in forced expiratory volume in 1 s (FEV1) among woodworkers in a 6-year follow-up study. Methods 817 woodworkers and 136 controls participated with cross-shift changes of FEV1 at baseline and FEV1 and forced vital capacity at follow-up. Height and weight were measured and questionnaire information on respiratory symptoms, employment and smoking habits was collected. Wood dust exposure was assessed from 3572 personal dust measurements at baseline and follow-up. Cumulative wood dust exposure was assessed by a study-specific job exposure matrix and exposure time. Results The median (range) of inhalable dust at baseline and cumulative wood dust exposure was 1.0 (0.2-9.8) mg/m3 and 3.8 (0-7.1) mg year/m3, respectively. Mean (SD) for %FEV1/workday and FEV1/year was 0.2 (6.0)%, and -29.1 (41.8) ml. Linear regression models adjusting for smoking, age, height and weight change showed no association between cross-shift and annual change in FEV1 among woodworkers or controls. Including different exposure estimates, atopy or cross-shift change dichotomised or as quartiles did not change the results. Conclusions This study among workers exposed to low levels of wood dust does not support an association between acute LF changes and accelerated LF decline.

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