Occupational Asthma Reference

Torén K, Zock J-P, Kogevinas M, Plana E, Sunyer J, Radon K, Jarvis D, Kromhout H, dErrico A, Payo F, Antó JM, Blanc PD, An international prospective general population based study of respiratory work disability, Thorax, 2009;64:339-344,
(Plain text: Toren K, Zock J-P, Kogevinas M, Plana E, Sunyer J, Radon K, Jarvis D, Kromhout H, dErrico A, Payo F, Anto JM, Blanc PD, An international prospective general population based study of respiratory work disability, Thorax)

Keywords: incidence, asthma, dust, vapours, fumes, incidence, epidemiology

Known Authors

Josep Antó, Barcelona, Catalonia, Spain Josep Antó

Kjell Toren, Sahlgrenska University Hospital. Goteborg Kjell Toren

Katja Radon, Ludwig Maximillian University, Munich Katja Radon

Paul Blanc, University of California San Francisco Paul Blanc

Jan-Paul Zock, Municipal Institute of Medical Research, Barcelona, Spain Jan-Paul Zock

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Background:
Previous cross-sectional studies have shown that job change due to breathing problems at the workplace (respiratory work disability) is common among adults of working age. That research indicated that occupational exposure to gases, dust and fumes was associated with job change due to breathing problems, although causal inferences have been tempered by the cross-sectional nature of previously available data. There
is a need for general population-based prospective studies to assess the incidence of respiratory work disability and to delineate better the roles of potential predictors of respiratory work disability.

Methods:
A prospective general population cohort study was performed in 25 centres in 11 European countries and one centre in the USA. A longitudinal analysis was undertaken of the European Community Respiratory Health Survey including all participants employed at any point since the baseline survey, 6659 subjects randomly sampled and 779 subjects comprising all subjects reporting physician-diagnosed asthma. The main outcome measure was new-onset respiratory work disability, defined as a reported job change during follow-up attributed to breathing problems. Exposure to dusts
(biological or mineral), gases or fumes during follow-up was recorded using a job-exposure matrix. Cox proportional hazard regression modelling was used to analyse such exposure as a predictor of time until job change due to breathing problems.

Results:
The incidence rate of respiratory work disability was 1.2/1000 person-years of observation in the random sample (95% CI 1.0 to 1.5) and 5.7/1000 person-years in the asthma cohort (95% CI 4.1 to 7.8). In the random
population sample, as well as in the asthma cohort, high occupational exposure to biological dust, mineral dust or gases or fumes predicted increased risk of respiratory work disability. In the random sample, sex was not associated with increased risk of work disability while, in the asthma cohort, female sex was associated with an increased disability risk (hazard ratio 2.8, 95% CI 1.3 to 5.9).

Conclusions:
Respiratory work disability is common overall. It is associated with workplace exposures that could be controlled through preventive measures.

Full Text

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo