Occupational Asthma Reference

Sjåheim T, Kongerud J, Søyseth V, Blood eosinophils in workers with aluminum potroom asthma are increased to higher levels in non-smokers than in smokers., Am J Industr Med, 2007;50:443-448,
(Plain text: Sjaheim T, Kongerud J, Soyseth V, Blood eosinophils in workers with aluminum potroom asthma are increased to higher levels in non-smokers than in smokers., Am J Industr Med)

Keywords: norway, aluminium, eosinophilia, potroom asthma

Known Authors

Johny Kongerud, Rikshospitalet, Oslo University, Norway Johny Kongerud

V Soyseth, Hydro Aluminium Aardal, Norway V Soyseth

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Abstract

BACKGROUND: Aluminum potroom asthma (PA) has been described in several reports. This study aimed to investigate the association between blood eosinophils and PA.

METHODS: In a cross-sectional study, 338 workers were examined as follows: spirometry, blood eosinophils, skin prick test, and work exposure measurements. They also completed a questionnaire on respiratory symptoms, smoking, allergy, and duration of work exposure.

RESULTS: The odds ratio for PA was 4.2 (95% confidence interval 1.5-9.7) for workers with eosinophils > or =400 x 10(6) cells/L compared with workers with eosinophils <200 x 10(6) cells/L. In non-smokers, the number of eosinophils was 177 x 10(6) cells/L (P < 0.001) higher among workers with PA than asymptomatic workers, whereas the corresponding difference among current smokers was only 63 x 10(6) cells/L (P = 0.03).

CONCLUSIONS: The prevalence of PA was positively associated with blood eosinophils. An attenuation of the blood eosinophil increase was observed in smoking asthmatics, suggesting an immune-modulating effect of smoking.

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