Occupational Asthma Reference

Moore VC, Jaakkola MS, Burge CBSG, Robertson AS, Pantin CF, Vellore AD, Burge PS, A New Diagnostic Score for Occupational Asthma, Chest, 2009;135:307-314,

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Known Authors

Sherwood Burge, Oasys Sherwood Burge

Charles Pantin, Keele, UK Charles Pantin

Vicky Moore, Oasys Vicky Moore

Cedd Burge, Oasys Cedd Burge

Alastair Robertson, Selly Oak Hospital Alastair Robertson

Arun Dev Vellore, Oasys Arun Dev Vellore

Maritta Jaakkola, Oulu University Finland Maritta Jaakkola

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Abstract

Evidence-based guidelines recommend serial peak expiratory flow (PEF) measurements on days at and away from work as the first step in the objective confirmation of occupational asthma. The aim of this study was to improve the diagnostic value of computer-based PEF analysis by calculating a score from the area between the curves (ABC) of PEF on days at and away from work in Oasys.

Mean 2-hourly PEFs were plotted separately for work days and rest days for 109 workers with occupational asthma and 117 control asthmatics. A score based on the ABC was computed from records containing >= 4 day shifts, >= 4 rest days and >= 6 readings per day. Patients were randomly divided into 2 datasets (analysis and test sets). Receiver operator characteristic (ROC) curve analysis determined a cut off point from Set 1 that best identified those with occupational asthma, which was then tested in Set 2. Logistic regression analysis showed that all ABC PEF scores were significant predictors of occupational asthma, with the best being ABC per hour from waking (odds ratio= 11.9 per 10L/hour/min; 95% CI 10.8-13.1). ROC curve analysis showed that a difference of 15 l/min/hour provided a high specificity without compromising sensitivity for occupational asthma diagnosis.

Analysis of dataset 2 confirmed a specificity of 100% and sensitivity of 72%. The ABC PEF score is sensitive and specific for the diagnosis of occupational asthma and can be calculated from a shorter PEF surveillance than is needed for the current Oasys-2 work effect index.

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