Occupational Asthma Reference

Anees W, Moore VC, Burge PS, FEV1 decline in occupational asthma, Thorax, 2006;61:751-755,

Keywords:

Known Authors

Sherwood Burge, Oasys Sherwood Burge

Wasif Anees, Oasys Wasif Anees

Vicky Moore, Oasys Vicky Moore

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Background: In occupational asthma continued workplace exposure to the causative agent is associated with a poor prognosis. However, there is little information available on how rapidly lung function declines in those who continue to be exposed, nor how removal from exposure affects lung function.
Methods: We studied FEV1 in 156 consecutive subjects with occupational asthma (87% due to low molecular weight agents) using simple regression analyses to provide estimates of FEV1 decline before and after removal from exposure.
Results: In 90 subjects who had FEV1 measurements made over at least a year prior to removal (median 2.9 years), mean rate of FEV1 decline was 100.9 ml per year (standard error 17.7). One year after removal from exposure, FEV1 had improved by 12.3 ml (standard error 31.6). FEV1 declined at an average of 26.6 ml per year (standard error 18ml) in 86 subjects who had measurements over at least one year (median 2.6 years) following removal from exposure. FEV1 decline was not significantly worse in current versus never smokers, nor was it affected by use of inhaled corticosteroids.
Conclusion: FEV1 declines rapidly in exposed workers with occupational asthma. Following removal from exposure FEV1 continued to decline but at a slower rate, similar to the rate of decline in healthy adults.

Full Text

Associated Questions

Registered users of this website have associated this reference with the following questions. This association is not a part of the BOHRF occupational asthma guidelines.

What is the prognosis of occupational asthma?
Cedd Burge Partial relocation not effective in reducing FEV1 decline
Which factors increase the probability of a favourable prognosis after a diagnosis of occupational asthma?
Cedd Burge Complete removal from exposure required to reduce accelerated FEV1 decline
What is the effect of inhaled corticosteroids on recovery from occupational asthma?
Cedd Burge No measureable benefit in FEV1 decline
What evidence is there for benefit of redeployment within the same workplace?
Cedd Burge Needs complete removal from exposure to influence accelerated FEV1 decline

Please Log In or Register to put forward this reference as evidence to a question.

Comments

FEV1 decline is accelerated after sensitisation even with inhaled corticosteroids and reduction of exposure. After complete removal there is initial improvement in FEV1 (which is relatively small), before FEV1 decline returns to normal levels. The evidence relates to a mixture of low molecular weight agents.
4/18/2008

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo