Occupational Asthma Reference

O'Brien IM, Harries MG, Burge PS, Pepys J, Toluene di-isocyanate-induced asthma. I. Reactions to TDI, MDI, HDI and histamine, Clin Allergy, 1979;9:1-6,

Keywords: oa, asthma, TDI, MDI, HDI, br, isocyanate

Known Authors

Sherwood Burge, Oasys Sherwood Burge

Jack Pepys, Royal Brompton Hospital Jack Pepys

Mark Harries, Brompton Hospital and Northwick Park Mark Harries

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

A group of twenty four workers handling di-isocyanates and with respiratory disease were investigated by occupational-type bronchial provocation tests for sensitivity to toluene di-isocyanate (TDI), to which all were exposed, and to diphenylmethane di-isocyanate (MDI) and hexamethylene di-isocyanate (HDI). Sixteen gave asthmatic reactions to TDI and eight of these also reacted to MDI. Four of the eight TDI and MDI reactors had histories of exposure only to TDI, and of them two reacted also to HDI. Of nine subjects tested with HDI, three gave asthmatic reactions, and all three also reacted to TDI and MDI. Thus reactions to MDI and HDI were elicited only in the TDI reactors. The possibility of specific sensitivity to these and other di-isocyanates requires tests in subjects exposed to them and not to TDI

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo