Occupational Asthma Reference

Brisman J, Lillienberg L, Belin L et al, Sensitisation To Occupational Allergens In Bakers' Asthma And Rhinitis: A Case-Referent Study, Int Arch Occup Environ Health, 2003;76:167-170,

Keywords:

Known Authors

Jonas Brisman, Sahlgrenska Hospital, Gothenburg Jonas Brisman

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Objectives. To study the importance of sensitisation to occupational allergens for the occurrence of asthma and rhinitis in bakers.

Methods. This is a nested clinical case-referent study of bakers based on a cohort of Swedish former bakery students. Cases were asthmatic (n=25) or rhinitic bakers (n=20). Randomly selected bakers (n=44) were referents. All subjects underwent skin prick tests (SPTs) with common allergens, flours, fungal a-amylase and the storage mite L. destructor. Indices of airway inflammation were assessed in serum and the nose.

Results. Seven of the asthmatics and eight of the rhinitics reported onset of disease during bakery work. Flour SPTs were positive in 43% of the asthmatics or rhinitics vs 16% of referents. The corresponding figures for a-amylase were 29%, 25%, and 7%. The odds ratio, adjusted for atopy, for an SPT positive to flour or a-amylase for asthmatics with onset during bakery work was 5.8 (95% confidence interval 1.1-32), and 2.6 (0.4-16) for the corresponding rhinitics. The positive predictive value of sensitisation to flour or a-amylase in relation to a clinical diagnosis of asthma or rhinitis was 71%. Sensitisation to L. destructor was rare. The indices of airway inflammation were similar in cases and in referents.

Conclusions. Bakers' asthma is associated with sensitisation to flour and/or a-amylase, atopy taken into account. A similar association was suggested in bakers' rhinitis. Indices of airway inflammation were of low predictive value for detecting bakers' asthma or rhinitis in this study.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Bohrf Occupational Asthma Guidelines

This reference has been analysed as part of the BOHRF occupational asthma guidelines. Please click to view the Bohrf occupational asthma guideline data for this reference.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo