Occupational Asthma Reference

Furusawa H, Peljto AL, Walts AD, Cardwell J, Molyneaux PL, Lee JS, PĂ©rez ERF, Wolters PJ, Yang IV, Schwartz DA, Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis, Thorax, 2022;77:508-510,http://dx.doi.org/10.1136/thoraxjnl-2021-217693
(Plain text: Furusawa H, Peljto AL, Walts AD, Cardwell J, Molyneaux PL, Lee JS, Perez ERF, Wolters PJ, Yang IV, Schwartz DA, Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis, Thorax)

Keywords: HP, fibrotic HP, genes, MUS5B, TERC, USA, IVD, DSP

Known Authors

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in TERC, DSP, MUC5B and IVD were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

This paper suggests that a patients genes, particularly MUC5B and those related to short telomers, are the underlying reason why some patients with hypersensitivity pneumonitis develop the fibrotic variant. It implies, although is not stated, that the genes are more important than cessation of exposure to the progression to fibrosis.
4/13/2022

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo