Occupational Asthma Reference

OrianneDumas, B├ędard A, Marbac M, Sedk M, SofiaTemam, Chanoine S, Severi G, Boutron-Ruault M, Garcia-Aymerich J, Siroux V, Varraso R, Moual NL, Household cleaning and poor asthma control among elderly women., J Allergy Clin Immunol Pract, 2021;:,https://doi.org/10.1016/j.jaip.2021.02.022
(Plain text: OrianneDumas, Bedard A, Marbac M, Sedk M, SofiaTemam, Chanoine S, Severi G, Boutron-Ruault M, Garcia-Aymerich J, Siroux V, Varraso R, Moual NL, Household cleaning and poor asthma control among elderly women., J Allergy Clin Immunol Pract)

Keywords: cleaner, sprayed cleaners, France, asthma

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Abstract

BACKGROUND:
Asthma control is suboptimal in nearly half of adults with asthma. Household exposure to disinfectants and cleaning products (DCP) has been associated with adverse respiratory effects, but data on their association with asthma control are scant.

OBJECTIVES:
To investigate the association between household use of DCP and asthma control in a large cohort of French elderly women.

METHODS:
We used data from a case-control study on asthma (2011-2013) nested in the E3N cohort. Among 3,023 women with current asthma, asthma control was defined by the Asthma Control Test (ACT). We used a standardized questionnaire to assess the frequency of cleaning tasks and DCP use. We also identified household cleaning patterns using a clustering approach. Associations between DCP and ACT were adjusted for age, smoking status, body mass index and education.

RESULTS:
Data on ACT and DCP use were available for 2,223 women (70±6 years old). Asthma was controlled (ACT=25), partly controlled (ACT=20-24) and poorly controlled (ACT=19) in 29%, 46% and 25% of the participants, respectively. Weekly use of sprays and chemicals were associated with poorly controlled asthma (odds ratio [95%CI]: 1 spray: 1.31 [0.94-1.84], =2 sprays: 1.65 [1.07-2.53], P-trend: 0.01; 1 chemical: 1.24 [0.94-1.64], =2 chemicals: 1.47 [1.03-2.09], P-trend: 0.02). Risk for poor asthma control increased with the patterns "very frequent use of products" (1.74 [1.13-2.70]) and "infrequent cleaning tasks and intermediate use of products" (1.62 [1.05-2.51]).


CONCLUSION: Regular use of DCP may contribute to poor asthma control in elderly women. Limiting their use may help improve asthma management.

Plain text: BACKGROUND: Asthma control is suboptimal in nearly half of adults with asthma. Household exposure to disinfectants and cleaning products (DCP) has been associated with adverse respiratory effects, but data on their association with asthma control are scant. OBJECTIVES: To investigate the association between household use of DCP and asthma control in a large cohort of French elderly women. METHODS: We used data from a case-control study on asthma (2011-2013) nested in the E3N cohort. Among 3,023 women with current asthma, asthma control was defined by the Asthma Control Test (ACT). We used a standardized questionnaire to assess the frequency of cleaning tasks and DCP use. We also identified household cleaning patterns using a clustering approach. Associations between DCP and ACT were adjusted for age, smoking status, body mass index and education. RESULTS: Data on ACT and DCP use were available for 2,223 women (70+-6 years old). Asthma was controlled (ACT=25), partly controlled (ACT=20-24) and poorly controlled (ACT<=19) in 29%, 46% and 25% of the participants, respectively. Weekly use of sprays and chemicals were associated with poorly controlled asthma (odds ratio [95%CI]: 1 spray: 1.31 [0.94-1.84], >=2 sprays: 1.65 [1.07-2.53], P-trend: 0.01; 1 chemical: 1.24 [0.94-1.64], >=2 chemicals: 1.47 [1.03-2.09], P-trend: 0.02). Risk for poor asthma control increased with the patterns "very frequent use of products" (1.74 [1.13-2.70]) and "infrequent cleaning tasks and intermediate use of products" (1.62 [1.05-2.51]). CONCLUSION: Regular use of DCP may contribute to poor asthma control in elderly women. Limiting their use may help improve asthma management.

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