Occupational Asthma Reference

Hendrick DJ, Connolly MJ, Stenton SC, Bird AG, Winterton IS, Walters EH, Occupational asthma due to sodium iso-nonanoyl oxybenzene sulphonate, a newly developed detergent ingredient, Thorax, 1988;43:501-502,

Keywords: oa, as , isononanoyloxybenzene, nc, detergent, ch, SINOS

Known Authors

Chris Stenton, Newcastle upon Tyne, UK Chris Stenton

David Hendrick, Newcastle-upon-Tyne David Hendrick

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Abstract



Research with sodium iso-nonanoyl oxybenzene sulphonate (SINOS) for use in a detergent product was complicated by the development of asthma in an atopic 38 year old laboratory technician. Inhalation challenge tests with nebulised SINOS solutions over a dose range of 0.01-32 micrograms gave reproducible late asthmatic reactions after the higher doses and an increase in bronchial responsiveness to methacholine. The magnitude of the late reaction was related to the challenge dose.






Research with sodium iso-nonanoyl oxybenzene sulphonate (SINOS) for use in a detergent product was complicated by the development of asthma in an atopic 38 year old laboratory technician. Inhalation challenge tests with nebulised SINOS solutions over a dose range of 0.01-32 micrograms gave reproducible late asthmatic reactions after the higher doses and an increase in bronchial responsiveness to methacholine. The magnitude of the late reaction was related to the challenge dose.



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