Occupational Asthma Reference

Jones M, Laboratory Animal Allergy in the Modern Era, Curr Allergy Asthma Rep, 2015;15:73,DOI 10.1007/s11882-015-0575-4

Keywords: laboratory animal, rat, mouse, review

Known Authors

Meinir Jones, Royal Brompton Hospital, London Meinir Jones

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Laboratory animal workers face a high risk of developing laboratory animal allergy as a consequence of inhaling animal proteins at work; this has serious consequences for their health and future employment. Exposure to animal allergen remains to be the greatest risk factor although the relationship is complex, with attenuation at high allergen exposure. Recent evidence suggests that this may be due to a form of natural immunotolerance. Furthermore, the pattern of exposure to allergen may also be important in determining whether an allergic or a tolerant immune response is initiated. Risk associated with specific tasks in the laboratory need to be determined to provide evidence to devise a code of best practice for working within modern laboratory animal facilities. Recent evidence suggests that members of lipocalin allergens, such as Mus m 1, may act as immunomodulatory proteins, triggering innate immune receptors through toll-like receptors and promoting airway laboratory animal allergy. This highlights the need to understand the relationship between endotoxin, animal allergen and development of laboratory animal allergy to provide a safe working environment for all laboratory animal workers.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo