Occupational Asthma Reference

Carneiro-Leão L, Amaral L, Silva D, Bartolomé B, Miranda M, Exploring a rare case of occupational senna allergy, Occup Med, 2018;68:641-643,https://doi.org/10.1093/occmed/kqy159
(Plain text: Carneiro-Leao L, Amaral L, Silva D, Bartolome B, Miranda M, Exploring a rare case of occupational senna allergy, Occup Med)

Keywords: Senna, IgE. prick test, cassia angustifolia, cr, pharmaceutical warehouse, or, oa, conjunctival provocation test, Spain

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Abstract

Background
Cassia angustifolia, or senna, is a plant belonging to the Fabaceae family, widely used as a laxative and as a colouring agent in hair dyes. Senna is rarely reported as an occupational allergic sensitizer in the current literature.

Aims
To describe the case and diagnostic approach of a suspected occupational senna allergy.

Case report
A male phytopharmaceutical warehouse worker reported bronchial, conjunctival and nasal symptoms immediately upon exposure to senna. We were able to document in vitro sensitization, finding IgE-binding proteins in senna, and in vivo sensitization through positive skin tests and conjunctival provocation test.

Conclusion
Our study confirms that senna may cause occupational rhinoconjunctivitis symptoms with an IgE-dependent mechanism and is the first to confirm it through specific conjunctival provocation test.

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