Occupational Asthma Reference

Gimenez A, Storrer K, Kuranishi L, Soares MR, Ferreira RG, Pereira CAC, Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis, Thorax, 2018;73:391-394,http://dx.doi.org/10.1136/thoraxjnl-2017-210035

Keywords: Brazil, HP, EAA, prognosis, histology

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Abstract

The predictive value of the decline in FVC by =10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with =10%?decline in predicted FVC after 6–12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69?vs 139 months, 95%?CI 66 to 212 months, p=0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by =10% (HR 4.13, 95%?CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95%?CI 0.04 to 0.77, p=0.021).

Plain text: The predictive value of the decline in FVC by >=10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with >=10% decline in predicted FVC after 6-12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p=0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by >=10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).

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