Occupational Asthma Reference

Mason P, Scarpa, MC, Liviero F, Guarnieri G, Maestrelli,P, Distinct Clinical Phenotypes of Occupational Asthma due to Diisocyanates, J Occup Environ Med, 2017;59:539-542,doi: 10.1097/JOM.0000000000001017

Keywords: Isocyanate, Italy, phenotype, challenge, OA,

Known Authors

Piero Maestrelli, Padova University, Italy Piero Maestrelli

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Objective:
To assess whether diisocyanate occupational asthma represents a unique phenotype.

Methods:
We studied 187 patients with diagnosis of asthma due to diisocyanates confirmed by a positive specific inhalation challenge. The simplified algorithm from severe asthma research program (SARP) (Moore et al, 2010) was applied to classify patients into five clusters.

Results:
Our patients were allocated in three of the five clusters described in common asthma, since the most severe Clusters (4 and 5) were not represented. Cluster 2 was the most populated, as in common asthma, and included the youngest patients with the shortest duration of exposure to the sensitizers. Cluster 3 included older men patients with worse lung function and longer occupational exposure.

Conclusions:
Diisocyanate asthma is a heterogeneous disease. Differences across clusters include demographic characteristics, lung function, and chronology of diisocyanate exposure.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo