Occupational Asthma Reference

Jones M, Blair S, MacNeill S, Welch J, Hole A, Baxter P, Cullinan P, Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers, Occup Environ Med, 2017;74:422-425,http://dx.doi.org/10.1136/oemed-2016-103834

Keywords: uk, fruit fly. drosophila, ep, cs, IgE, dose response,

Known Authors

Paul Cullinan, Royal Brompton Hospital, London, UK Paul Cullinan

Meinir Jones, Royal Brompton Hospital, London Meinir Jones

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Abstract

Objectives
Drosophila melanogaster (the ‘fruit fly’) is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. Our aim in this study is to determine the prevalence and determinants of sensitisation to fruit flies in a population of exposed workers.

Methods
In a cross-sectional study, we surveyed 286 employees working in a department carrying out research involving D. melanogaster. Sensitisation was assessed by specific IgE measurement in serum and examined in relation to symptoms and to estimated exposure to fruit flies.

Results
The overall prevalence of specific sensitisation was 6% with a clear relationship to increasing frequency/intensity of exposure (p trend<0.001). Work-related eye/nose, chest or skin symptoms were reported by substantial proportions of participants but for most of these there was no evidence of specific sensitisation to fruit fly. The overall prevalence of any work-related symptoms and sensitisation was 2.4%, rising to 7.1% in those working in high exposure groups.

Conclusions
We were able to demonstrate, for the first time, a clear exposure–response relationship between fruit fly exposure and specific sensitisation. Facilities housing fruit flies should carefully consider methods to reduce exposure levels in the workplace.

Plain text: Objectives Drosophila melanogaster (the 'fruit fly') is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. Our aim in this study is to determine the prevalence and determinants of sensitisation to fruit flies in a population of exposed workers. Methods In a cross-sectional study, we surveyed 286 employees working in a department carrying out research involving D. melanogaster. Sensitisation was assessed by specific IgE measurement in serum and examined in relation to symptoms and to estimated exposure to fruit flies. Results The overall prevalence of specific sensitisation was 6% with a clear relationship to increasing frequency/intensity of exposure (p trend<0.001). Work-related eye/nose, chest or skin symptoms were reported by substantial proportions of participants but for most of these there was no evidence of specific sensitisation to fruit fly. The overall prevalence of any work-related symptoms and sensitisation was 2.4%, rising to 7.1% in those working in high exposure groups. Conclusions We were able to demonstrate, for the first time, a clear exposure-response relationship between fruit fly exposure and specific sensitisation. Facilities housing fruit flies should carefully consider methods to reduce exposure levels in the workplace.

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Associated Questions

Registered users of this website have associated this reference with the following questions. This association is not a part of the BOHRF occupational asthma guidelines.

Which agents cause occupational asthma and which workers are at risk?
burgeps Clear dose-response to exposure to the fruit fly in laboratory workers

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Comments

This study shows a clear dose-response for frequency/intensity of exposure for specific IgE to fruit flies (5% low and frequent, 15% high and frequent) and work-related symptoms (chest symptoms 10% vs. 17%). There are a much larger number with work-related symptoms and no specific IgE (>30%) . The cause for their symptoms, and their exposure to other possible causes were not determined. The response rate to this cross-sectional study was 21%.
6/6/2017

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