Occupational Asthma Reference

Barber CM, Wiggans RE, Young C, Fishwick D, UK asbestos imports and mortality due to idiopathic pulmonary fibrosis, Occup Med, 2016;66:106-111,10.1093/occmed/kqv142

Keywords: key,uk, asbestos, ipf, mesothelioma, ep, incidence

Known Authors

David Fishwick, Royal Hallamshire Hospital, Sheffield, UK David Fishwick

Chris Barber, Health and Safety Laboratories, Buxton Chris Barber

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Abstract

Background
Previous studies have demonstrated that the rising mortality due to mesothelioma and asbestosis can be predicted from historic asbestos usage. Mortality due to idiopathic pulmonary fibrosis (IPF) is also rising, without any apparent explanation.

Aims
To compare mortality due to these conditions and examine the relationship between mortality and national asbestos imports.

Methods
Mortality data for IPF and asbestosis in England and Wales were available from the Office for National Statistics. Data for mesothelioma deaths in England and Wales and historic UK asbestos import data were available from the Health & Safety Executive. The numbers of annual deaths due to each condition were plotted separately by gender, against UK asbestos imports 48 years earlier. Linear regression models were constructed.

Results
For mesothelioma and IPF, there was a significant linear relationship between the number of male and female deaths each year and historic UK asbestos imports. For asbestosis mortality, a similar relationship was found for male but not female deaths. The annual numbers of deaths due to asbestosis in both sexes were lower than for IPF and mesothelioma.

Conclusions
The strength of the association between IPF mortality and historic asbestos imports was similar to that seen in an established asbestos-related disease, i.e. mesothelioma. This finding could in part be explained by diagnostic difficulties in separating asbestosis from IPF and highlights the need for a more accurate method of assessing lifetime occupational asbestos exposure.

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