Occupational Asthma Reference

Svanes Ø, Skorge TD, Johannessen A, Bertelsen RJ, Bråtveit M, Forsberg B, Gislason T, Holm M, Janson C, Jögi R, Macsali F, Norbäck D, Omenaas ER, Real FG, Schlünssen V, Sigsgaard T, Wieslander G, Zock J, Aasen T, Dratva J, Svanes C, Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?, PLoS ONE, 2015;10:e0131959,10.1371/journal.pone.0131959
(Plain text: Svanes O, Skorge TD, Johannessen A, Bertelsen RJ, Bratveit M, Forsberg B, Gislason T, Holm M, Janson C, Jogi R, Macsali F, Norback D, Omenaas ER, Real FG, Schlunssen V, Sigsgaard T, Wieslander G, Zock J, Aasen T, Dratva J, Svanes C, Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?, PLoS ONE)

Keywords: cleaner, ep,

Known Authors

Torben Sigsgaard, University of Aarhus Torben Sigsgaard

Tor Aasen, Haukeland University Hospital, Bergen Tor Aasen

Jan-Paul Zock, Municipal Institute of Medical Research, Barcelona, Spain Jan-Paul Zock

Vivi Schlunssen, Aarhus Vivi Schlunssen

Dan Norback, Dan Norback

Cecile Svanes, University of Bergen, Norway Cecile Svanes

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Rationale
There is some evidence that maternal smoking increases susceptibility to personal smoking’s detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational exposure.

Objectives
In this cross-sectional study we investigated respiratory symptoms, asthma and self-reported chronic obstructive pulmonary disease (COPD) as related to working as a cleaner in Northern European populations, and whether early life factors influenced susceptibility to occupational cleaning’s unhealthy effects.

Methods
The RHINE III questionnaire study assessed occupational cleaning in 13,499 participants. Associations with respiratory symptoms, asthma and self-reported COPD were analysed with multiple logistic regressions, adjusting for sex, age, smoking, educational level, parent´s educational level, BMI and participating centre. Interaction of occupational cleaning with early life disadvantage (maternal smoking, severe respiratory infection <5 years, born during winter months, maternal age at birth >35 years) was investigated.

Main Results
Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3–1.6), adult-onset asthma (1.5 [1.2–1.8]) and self-reported COPD (1.7 [1.3–2.2]) were increased. The risk increased with years in occupational cleaning (adult-onset asthma: =1 year 0.9 [0.7–1.3]; 1–4 years 1.5 [1.1–2.0]; =4 years 1.6 [1.2–2.1]). The association of wheeze with cleaning activity =4 years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5–2.3] vs. 1.3 [0.96–1.8]; pinteraction 0.035).

Conclusions
Occupational cleaners had increased risk of asthma and self-reported COPD. Respiratory symptom risk was particularly increased in persons with factors suggestive of early life disadvantage. We hypothesize that early life disadvantage may increase airway vulnerability to harmful exposure from cleaning agents later in life.

Plain text: Rationale There is some evidence that maternal smoking increases susceptibility to personal smoking's detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational exposure. Objectives In this cross-sectional study we investigated respiratory symptoms, asthma and self-reported chronic obstructive pulmonary disease (COPD) as related to working as a cleaner in Northern European populations, and whether early life factors influenced susceptibility to occupational cleaning's unhealthy effects. Methods The RHINE III questionnaire study assessed occupational cleaning in 13,499 participants. Associations with respiratory symptoms, asthma and self-reported COPD were analysed with multiple logistic regressions, adjusting for sex, age, smoking, educational level, parent's educational level, BMI and participating centre. Interaction of occupational cleaning with early life disadvantage (maternal smoking, severe respiratory infection <5 years, born during winter months, maternal age at birth >35 years) was investigated. Main Results Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3-1.6), adult-onset asthma (1.5 [1.2-1.8]) and self-reported COPD (1.7 [1.3-2.2]) were increased. The risk increased with years in occupational cleaning (adult-onset asthma: <=1 year 0.9 [0.7-1.3]; 1-4 years 1.5 [1.1-2.0]; >=4 years 1.6 [1.2-2.1]). The association of wheeze with cleaning activity >=4 years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5-2.3] vs. 1.3 [0.96-1.8]; pinteraction 0.035). Conclusions Occupational cleaners had increased risk of asthma and self-reported COPD. Respiratory symptom risk was particularly increased in persons with factors suggestive of early life disadvantage. We hypothesize that early life disadvantage may increase airway vulnerability to harmful exposure from cleaning agents later in life.

Full Text

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo