Stainless steel welding asthma shows active inflammation from differentially expressed genes, not seen with isocyanates or flour

This is a complicated study investigating molecular mechanisms of work-related asthma due to flour, isocyanates and stainless steel welding. The welders were the only group showing active inflammation from differentially expressed genes in nasal mucosal biopsies, but asymptomatic welders were not included in the controls. All three groups showed activation of genes associated with neutrophil migration and degranulation. The numbers are rather small for generating associations from these three very different agents that can cause indistinguishable clinical disease.

References

	Suojalehto H, Ndika J, Lindström I, Airaksinen L, Karisola P, Alenius H, Endotyping asthma related to three different work exposures, J Allergy Clin Immunol, 2021;148:1070-1080,https://doi.org/10.1016/j.jaci.2021.07.019

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