Significant late asthmatic reactions defined by values outside 95% CI for control days identifies late reactions with smaller changes in FEV1

Specific inhalation tests are more difficult to perform in workers who have isolated late asthmatic reactions, as more caution is needed increasing exposures. Defining a late asthmatic reaction outside the 95% CI for control days allows identification of late reactions with lower percentage change in FEV1 in those with initial values >2.5 litres, however 3 control days are needed. This paper reports the results when 2 of the 3 control days are done unsupervised at home, with the third day following control exposure in the laboratory. The pooled SD method for defining late asthmatic reactions has scientific validity, accounts for interpatient spirometric variability and diurnal variation.

References

	Moore VC, Walters GI, Robertson AS, Burge PS, Identification of late asthmatic reactions following specific inhalation challenge, Occup Environ Med, 2020;77:728-731,doi.org/10.1136/oemed-2020-106436

Comments