4,4-methylene-bismorpholine; new cause of occupational asthma |
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| Agent |
4,4-methylene-bismorpholine (biocide in metalworking fluid) |
| Job |
machine tool setter operator |
| Specific IgE |
not done |
| Skin prick test |
positive to 4,4-methylene-bismorpholine (3mm) |
| Non-specific reactivity |
normal (>4800ug Jan) at work, 587ug post SIC |
| Serial Peak Flow |
Positive Oasys score 3.4, ABC 23.4 l/min/hr |
| Induced sputum |
not done |
| FENO |
71ppb exposed |
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| Specific Challenge |
positive to 0.7% in water with dual reaction with rhinitis |
| Follow-up |
dismissed from work, asthma continued, FeNO 56ppb 9 months later |
References
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Walters GI, Moore VC, Robertson AS, McGrath EE, Parkes E, Burge PS,
Occupational asthma from sensitization to 4, 4-methlyene bismorpholine in clean metalworking fluid,
Eur Respir J,
2013;42:1137-1139,
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