Occupational asthma in a pharmaceutical worker due to Aescin (new cause, well fairly new) |
|
| Agent |
Aescin (mixture of saponins from Aesculus hippocastanum, horse chestnut) |
| Job |
pharmaceutical manufacture worker with 20 year latent interval |
| Specific IgE |
not done |
| Skin prick test |
not done |
| Non-specific reactivity |
Methacholine PC20 1mg/ml; 6 months after exposure control 6mg/ml |
| Serial Peak Flow |
positive |
| Induced sputum |
not done |
| Specific Challenge |
Pronlonged immediate/late asthmatic reaction to 5g aescin mixed with 150g lactose tipped for 5 minutes with negative lactose and plantago control |
| Follow-up |
asymptomatic 6 months after relocation away from exposure |
References
Comments
Also reported in 2006:
Horse chestnut extract: First report of occupational asthma: case report
Source: Reactions, Volume 1, Numbers 1097-1098, 2006-04-15 , pp. 15-15(1)
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