Asthma in a chemist due to TBTU (new cause) |
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| Agent |
TBTU (2-[1H-benzotriazol-1-yl]-1,1,3,3-tetramethyluronium tetrafluoroborate) |
| Job |
chemist in peptide laboratory |
| Specific IgE |
negative with TBTU/albumin conjugate with immunoCAP |
| Skin prick test |
positive 1mg/ml (also to HBTU) |
| Non-specific reactivity |
Histamine 26.7mg/ml post lactose challenge (normal) and 1.84 mg/ml post TBTU |
| Serial Peak Flow |
not done |
| Induced sputum |
Eosinophils 0.3% pre and 6.3% post TBTU challenge |
| Specific Challenge |
Immediate asthmatic reaction to TBTU undiluted tipped for 60 minutes with negative lactose control |
| Follow-up |
improved with RPE, enclosure and ventilation |
References
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Vandenplas O, Hereng M-P, Heymans J, Huaux F, Lilet-Leclercq C, Dezfoulian B, Grand J-L, Thimpont J,
Respiratory and skin hypersensitivity reactions caused by a peptide coupling reagent,
Occup Environ Med,
2008;65:715-716,
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