Nickel Fumes

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Known Synonyms

Nickel
Nickel Spray
Nickel is a potential cause of occupational asthma, where it can be inhaled. This happens when electroplating and welding stainless steel. 

Several studies report positive specific inhalation challenge tests using nebulised nickel chloride at 0.1-10 mg/ml and nickel sulphate at 10 mg/ml.

Several studies report the use of skin prick tests using Nickel Sulphate at 10 mg/ml in patients with confirmed occupational asthma to Nickel. These are positive in some patients and negative in others.

Specific IgE tests are also possible using nickel-conjugated human serum albumin (Ni-HSA), and nickel-conjugated exchange resin (Ni-resin) and NiSO4-human serum albumin. These are positive in some patients with confirmed occupational asthma to Nickel but negative in others, suggestive that in at least some cases the asthma is IgE mediated.

Occupational asthma to Nickel can occur within the current exposure standards and there may be cross reactivity with chrome and cobalt.

Preventative measures include extraction and respiratory protective equipment (RPE). Workers not directly exposed can be protected by enclosing areas where the Nickel fume is produced.

Nickel Carbonyl can cause acute pneumonitis, nickel and nickel alloys are possible human carcinogens; nickel compounds are known human carcinogens.

References for: Nickel Fumes See published papers on "Nickel Fumes" from this website.
Haz-Map information on: Nickel Fumes See information on "Nickel Fumes" from the HazMap (Information on Hazardous Chemicals and Occupational Diseases) website.

Oasys Notifications for Nickel Fumes

The Oasys Audit scheme started midway through 2010 and collects agents typed in through the Oasys program. The years before 2010 show old data entered during 2010 or later and are likely to have many fewer notifications. We expect Oasys to become more widely adopted as time goes by so increasing notifications does not necessarily mean an increasing problem.

Occupational asthma notifications to the Oasys Audit Scheme for Nickel Fumes

Selected References for Nickel Fumes

Abstract Available for Occupational asthma due to chrome and nickel electroplating Bright P, Burge PS, O'Hickey SP, Gannon PF, Robertson AS, Boran A, Occupational asthma due to chrome and nickel electroplating, Thorax, 1997;52:28-32,
Sherwood Burge, Oasys, an author of 'Occupational asthma due to chrome and nickel electroplating' Paul Gannon, Dupont, an author of 'Occupational asthma due to chrome and nickel electroplating' Phil Bright, Oasys, an author of 'Occupational asthma due to chrome and nickel electroplating' Alastair Robertson, Selly Oak Hospital, an author of 'Occupational asthma due to chrome and nickel electroplating' Steve O'Hickey, Worcester Hospital, an author of 'Occupational asthma due to chrome and nickel electroplating'

Abstract Available for Lymphocyte transformation test with nickel in hard metal asthma: another sensitizing component of hard metal Kusaka Y, Nakano Y, Shirakawa T, Fujimura N, Kato M, Heki S, Lymphocyte transformation test with nickel in hard metal asthma: another sensitizing component of hard metal, Ind Health, 1991;29:153-160,
N Fujimura, Kyoto, an author of 'Lymphocyte transformation test with nickel in hard metal asthma: another sensitizing component of hard metal'

Full Text Available for Hard metal asthma: cross immunological and respiratory reactivity between cobalt and nickel? Shirakawa T, Kusaka Y, Fujimura N, Kato M, Heki S, Morimoto K, Hard metal asthma: cross immunological and respiratory reactivity between cobalt and nickel?, Thorax, 1990;45:267-271,
N Fujimura, Kyoto, an author of 'Hard metal asthma: cross immunological and respiratory reactivity between cobalt and nickel?'

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