Amylase is the principal enzyme adding to baking flour as an improver and is a common cause of bakers asthma. IgE are usually present.
There are other sources of exposure outside of baking.
The Oasys Audit scheme started midway through 2010 and collects agents typed in through the Oasys program. The years before 2010 show old data entered during 2010 or later and are likely to have many fewer notifications. We expect Oasys to become more widely adopted as time goes by so increasing notifications does not necessarily mean an increasing problem.