Is it possible to get occupational asthma from products with isopropyl alcohol?

A patient 42 years old clean car glasses in a factory with isopropyl alcohol products. He has respiratory symptoms, wheezing are present sometimes in the chest, he has rhinitis .We did not find eosynophils in nasal secretions.He has IgE very high and cutaneous allergen test negative. Methacolin test negative. Spirometry with and without salbutamol.PEF in the work are low. I can not find asthma association with alcohol products. Can you help me to analize this clinical case?

Occupational Asthma, Health Professional, 3/11/2009, 3/14/2009,

If there are significant differences between PEF on workdays compared with rest days your patient has occupational asthma. About 30% have normal methacholine reactivity at diagnosis, and more than 50% do not have sputum eosinophilia. As far as I am aware isopropyl alcohol alone has not been described as a cause of occupational asthma, but alcohol wipes have caused occupational asthma. It is likely that your product also contains biocides or stabilisers, which are more likely to cause occupational asthma than the isopropyl alcohol alone, but there is always a first time. This could be tested by specific inhalation testingt to unadulterated isopropyl alcohol, and comparing this with your product. Anees W, Huggins V, Pavord ID, Robertson AS, Burge PS, Occupational Asthma Due To Low Molecular Weight Agents : Eosinophilic And Non-Eosinophilic Variants, Thorax, 2002;57:231-236, Waclawski ER, McAlpine LG, Thomson NC, Occupational asthma in nurses due to chlorhexidine and alcohol aerosols, Br Med J, 1989;298:929-930,

3/14/2009