Reference

Piirila PL, Nordman H, Keskinen HM et al, Long-term follow-up of hexamethylene di-isocyanate-diphenylmethane di-isocyanate-, and toluene di-isocyanate-induced asthma, Am J Respir Crit Care Med, 2000;162:516-522,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study carried out on average 10 years after diagnosis. Patients with IgE-mediated asthma had significantly better prognosis than IgE negative patients. It proved to be partly due to shorter exposure and symptomatic periods before diagnosis. Hexamethylene di-isocyanate (HDI)-induced asthma was associated with a better outcome than diphenylmethane di-isocyanate (MDI) and toluene di-isocyanate (TDI)-induced asthma. Those who continued in their primary work place did not report more symptoms than those working in new work places. Early diagnosis and adequate medical surveillance, including active treatment and swift vocational rehabilitation, are equally essential for the patient's overall prognosis. No association between persistence of symptoms or need of medication with duration of exposure, duration of symptoms before diagnosis or the latency period.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have shorter duration of symptoms prior to diagnosis.

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have shorter duration of symptoms prior to avoidance of exposure.

Non Bohrf Information

This page is showing the information from the BOHRF occupational asthma guidelines for this reference. To see additional information, including opinions left by users of this website please view the full reference. This page allows users to comment on the reference and suggest it as evidence for questions. These may be the existing questions from the Bohrf occupational asthma guidelines or questions that have been put forward by users of this website.