Occupational Asthma Reference

ZAWODOWA A, PAPAINA W, PRZYPADKU O, PAPAIN-INDUCED OCCUPATIONAL RHINOCONJUNCTIVITIS AND ASTHMA – A CASE REPORT, Med Pracy, 2016;67:109-112,
(Plain text: ZAWODOWA A, PAPAINA W, PRZYPADKU O, PAPAIN-INDUCED OCCUPATIONAL RHINOCONJUNCTIVITIS AND ASTHMA - A CASE REPORT, Med Pracy)

Keywords: Poland, oa, case report,papain, OR, challenge, IgE, spice packer, sputum,

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Abstract

This report presents a case of occupational asthma, rhinitis and conjunctivitis to papain in a 50-year-old herbs and spices packer, with documented increased eosinophilia in induced sputum and in the nasal lavage fluids after a specific inhalation challenge
test (SICT) and specific nasal challenge test (SNCT) with this enzyme. Immunoglobulin E-mediated (IgE) sensitization to papain was confirmed by positive results of a skin prick test with specific solution. Specific inhalation and nasal challenge tests
demonstrated a direct and significant link between the exposure to this protease and the allergic response from the respiratory system. Additionally, the SNCT induced a severe reaction of the conjunctivae and a significant increase in the count of eosinophils in tears, despite the lack of direct contact of the allergen with the conjunctiva. Med Pr 2016;67(1):109–112

Plain text: This report presents a case of occupational asthma, rhinitis and conjunctivitis to papain in a 50-year-old herbs and spices packer, with documented increased eosinophilia in induced sputum and in the nasal lavage fluids after a specific inhalation challenge test (SICT) and specific nasal challenge test (SNCT) with this enzyme. Immunoglobulin E-mediated (IgE) sensitization to papain was confirmed by positive results of a skin prick test with specific solution. Specific inhalation and nasal challenge tests demonstrated a direct and significant link between the exposure to this protease and the allergic response from the respiratory system. Additionally, the SNCT induced a severe reaction of the conjunctivae and a significant increase in the count of eosinophils in tears, despite the lack of direct contact of the allergen with the conjunctiva. Med Pr 2016;67(1):109-112

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