Diesel fumes are a difficult topic. They contain a lot of ultrafine particles which bind other agents (and allergens) in the environment. Much of the work relates to increased asthma in the vicinity of major roads. There are descibed workers with occupational asthma for instance in bus garages, this is probably an example of irritant induced occupational asthma with latency, which is not accepted by all. There is also evidence of the irritant effects on the bronchial mucosa in normal people, I dont know of any good review of this but a number of relevant papers are attached
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Boutin-Forzano S, Hammou Y, Gouitaa M, Charpin D,
Air pollution and atopy,
European Annals of Allergy and Clinical Immunology,
2005;37:11-16,
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Devouassoux G, Saxon A, Metcalfe DD, Prussin C, Colomb MG, Brambilla C, Diaz-Sanchez D,,
Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils,
J Allergy Clin Immunol,
2002;109:847-853,
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Nightingale JA, Maggs R, Cullinan P, Donnelly LE, Rogers DF, Kinnersley R, Chung KF, Barnes PJ, Ashmore M, Newman-Taylor A,
Airway inflammation after controlled exposure to diesel exhaust particulates,
Am J Respir Crit Care Med,
2000;162:161-6,
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Nitta H, Sato T, Nakai S, Maeda K, Aoki S, Ono M,
Respiratory health associated with exposure to automobile exhaust. I. Results of cross-sectional studies in 1979, 1982, and 1983,
Arch Environ Health,
1993;48:53-58,
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