Reference

Bignon JS, Aron Y, Ju LY et al, HLA class II alleles in isocyanate-induced asthma, Am J Respir Crit Care Med, 1994;149:71-75,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

DQB1*0503 and allelic combination DQB1*0201/0301 were associated with susceptibility to isocyanate occupational asthma, whereas DQB1*0501 and DQA1*0101-DQB1*0501-DR conferred significant protection in exposed, healthy control subjects. Although a group of asthmatic subjects was not examined to rule out an association between HLA and asthma per se., the frequency of DR4 haplotype was lower than in atopic historical controls and similar to that in study controls.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

Non Bohrf Information

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