BOHRF Original Authors' Main Conclusions
The original authors' main conclusions are taken from Abstract, Results and
Discussion. They are decided upon by the authors of the BOHRF occupational
asthma guidelines and form part of the guidelines.
27 asthmatic and 20 non-asthmatic subjects were followed up 2 years after first examination. 15/27 asthmatics who continued exposure showed significant decrease in FEV1 and bronchial hyper-responsiveness and symptoms of chronic bronchitis. Non-asthmatics showed significant decrease of pulmonary function without changes in bronchial hyper-responsiveness. Conclude that stopping exposure to Toluene di-isocyanate (TDI) frequently did not produce an improvement of the TDI bronchial asthma, but in many cases symptoms of bronchoconstriction and bronchial hyper-responsiveness persist or may get worse. On the other hand, persistence of the occupational exposure causes a more rapid decline of the respiratory function.
BOHRF Associated Evidence Statements
The BOHRF occupational asthma guidelines state that this reference is associated
with the following evidence statements
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